Yersinia outer proteins: Yops
نویسندگان
چکیده
منابع مشابه
Characterization of outer membrane proteins of Yersinia pestis and Yersinia pseudotuberculosis strains isolated from India.
The majority of virulence factors including the 12 Yersinia outer membrane proteins (Yops), 29 Yop secretion proteins (Ysc) and few specific Yop chaperone (Syc) are contributed by the 70 kb LCR middle plasmid of Yersinia pestis. Yersinia pestis isolates recovered during 1994 plague outbreak and rodent surveillance samples of Southern states of India were studied for the presence of important Yo...
متن کاملExpression of the temperature-inducible outer membrane proteins of yersiniae.
The expression of the temperature-inducible plasmid-coded outer membrane proteins (YOPs) of Yersinia pseudotuberculosis was studied. These proteins were not recovered in the outer membrane fraction when the strain was grown in minimal medium at 37 degrees C, but they were expressed under these conditions. A strict correlation was found between Ca2+ dependency in the virulent strain, YPIII(pIB1)...
متن کاملRoles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica.
Yersinia enterocolitica target effector Yop proteins into the cytosol of eukaryotic cells by a mechanism requiring the type III machinery. LcrG and LcrV have been suggested to fulfill essential functions during the type III targeting of effector Yops. It is reported here that knockout mutations of lcrG caused mutant yersiniae to prematurely secrete Yops into the extracellular medium without abo...
متن کاملImmune response to Yersinia outer proteins and other Yersinia pestis antigens after experimental plague infection in mice.
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Such a model may replicate the clinical situation in humans and indicate which viru...
متن کاملMicroinjection of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption.
Introduction Three species of the genus Yersinia may produce disease in humans: they are Y. pestis, Y. pseudotuberculosis and Y. enterocolitica. Y pseudotuberculosis may cause fatal infection in rodents but produces only mild gastrointestinal disease in humans. Pathogenic Yersinia possess a common virulence plasmid of about 70 kb in size. Upon incubation at 37°C in the absence of CaZ+ ions, str...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2008
ISSN: 1462-5814,1462-5822
DOI: 10.1111/j.1462-5822.2007.01109.x